Friday, January 20, 2017

Restricted, Repetitive Patterns of Behavior (RRBs) and Comorbid Symptoms in Children on the Autism Spectrum


Children with autism spectrum disorder (ASD) frequently have co-occurring (comorbid) psychiatric symptoms, with rates significantly higher than would be expected from the general population. Research indicates that the most common co-occurring diagnoses are anxiety and depression, attention problems, and disruptive behavior disorders. Previous studies also suggest that restricted, repetitive patterns of behavior, interests, or activities (RRBs) are associated with the symptoms of co-occurring psychiatric conditions in individuals with ASD. 

The criteria for the new DSM-5 category of Autism Spectrum Disorder (ASD) continue to include RRBs as a core diagnostic feature, together with the domain of social communication and social interaction deficits. According to the DSM-5, restricted, repetitive patterns of behavior, interests, or activities are defined by the presence of at least two of the following:
  • Stereotyped or repetitive speech, motor movements, or use of objects; (such as simple motor stereotypies, echolalia, repetitive use of objects, or idiosyncratic phrases).
  • Excessive adherence to routines, ritualized patterns of verbal or nonverbal behavior, or excessive resistance to change; (such as motoric rituals, insistence on same route or food, repetitive questioning or extreme distress at small changes).
  • Highly restricted, fixated interests that are abnormal in intensity or focus; (such as strong attachment to or preoccupation with unusual objects, excessively circumscribed or perseverative interests).
  • Hyper-or hypo-reactivity to sensory input or unusual interest in sensory aspects of environment; (such as apparent indifference to pain/heat/cold, adverse response to specific sounds or textures, excessive smelling or touching of objects, fascination with lights or spinning objects.
RRBs have been shown to cause significant challenges for both the individual with ASD and his or her family. Likewise, they can impede learning and socialization by decreasing the likelihood of positive interactions with peers and adults. Parents of individuals with ASD also report that RRBs are one of the most challenging features of ASD due to their significant interference with daily life. In contrast with the core domain of social/communication deficits, RRBs have only recently been the focus of systematic research efforts.
                                                                     Research
Stratis and Lecavalier (2013) investigated the relationship between RRBs and co-occurring depressive, anxiety, attention-deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) symptoms, while considering level of functioning. Participants in the study were 72 parents of children and youth diagnosed with ASD (ages 5–17). Children’s co-occurring diagnoses included: Attention-Deficit/Hyperactivity Disorder (ADHD), Anxiety Disorders, Mood Disorders, Behavioral Disorders, and Intellectual Disability. Frequency and severity of RRBs were assessed across five domains: Stereotypic Behavior, Self-Injurious Behavior (SIB), Compulsive Behavior, Ritualistic/Sameness Behavior, and Restricted Interests. Ratings by parents were used to quantify co-occurring symptom severity for each of the following four domains: ADHD, ODD, anxiety disorders and depressive disorders. Data analyses were completed to determine which RRBs were most predictive of co-occurring symptom severity.
                                                                       Results
Children with high levels of ritualistic and sameness behavior tended to show more severe symptoms of anxiety and depression. This appears consistent with the high co-occurrence of depressive and anxiety symptoms in the general population. This finding also suggests that ritualistic and sameness behaviors may be implicated in the development and maintenance of anxiety in individuals with ASD. Interestingly, high levels of restricted interests were associated with less severe symptoms of depression, suggesting that restricted interests may be a protective factor against the development of depression. Although restricted interests frequently have a negative impact on interpersonal relationships, they might also have a positive effect by providing a feeling of self-validation and a means of occupying one’s time, while also serving as an incentive to increase knowledge. 
Inconsistent with previous research, all psychiatric symptom domains appeared unrelated to children’s level of functioning. However, level of functioning moderated the relationship of SIB and depressive and anxiety symptoms. For higher functioning children and youth, elevated levels of SIB were predictive of more severe depressive and anxiety symptoms whereas higher levels of SIB were predictive of less severe depressive and anxiety symptoms for lower functioning individuals. For lower functioning individuals, high levels of ritualistic and sameness behaviors predicted more severe depressive symptoms while there was no significant relationship for higher functioning individuals.
                                                                    Implications
The results of this study may help clarify the presentation of ASD phenotypes, suggesting that different types of RRBs may be predictive of co-occurring psychiatric disorders. This has implications for genetic and neurobiological research. For example, differences underlying genetic and neurobiological factors may be identified based on symptom presentation, including RRBs and co-occurring psychiatric symptoms. Moreover, if RRBs and psychiatric symptoms do share common etiologies, interventions for psychiatric symptoms may help ameliorate RRBs in individuals with ASD. The possibility that RRBs such ritualistic and sameness behaviors may be involved in development and maintenance of anxiety or that restricted interests protect against the development of depressive symptoms has significant implications for treatment and should be explored in future research. Given that RRBs continue to be a core feature of ASD in DSM-5, clinicians and practitioners should give increased attention to the assessment and presence of RRBs and their impact on common co-occurring disorders and psychological well-being of individuals with ASD.
Stratis, E. A., & Lecavalier, L. (2013).  Restricted and repetitive behaviors and psychiatric symptoms in youth with autism spectrum disorders. Research in Autism Spectrum Disorders, 7, 757–766.

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